Migration and invasion of oral squamous carcinoma cells is promoted by WNT5A, a regulator of cancer progression.

Summary, in English

Oral squamous cell carcinoma (OSCC) constitutes 90% of all cancers in the oral cavity, and the prognosis for patients diagnosed with OSCC is still poor. The identification of novel therapeutic targets and prognostic markers for OSCC is therefore essential. Previous studies of OSCC revealed an increased expression of WNT5A in the tumor tissue. However, no functional studies of WNT5A-induced effects in OSCC have been performed.

• Author: Zdenka Prgomet; Lena Axelsson; Pia Lindberg; Tommy Andersson
• Department/s: Experimental Pathology, Malmö; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publishing year: 2015
• Language: English
• Pages: 776-784
• Publication/Series: Journal of Oral Pathology & Medicine
• Volume: 44
• Issue: 10
• Links: http://www.ncbi.nlm.nih.gov/pubmed/25459554?dopt=Abstract; http://dx.doi.org/10.1111/jop.12292
• Document type: Journal article
• Publisher: Wiley-Blackwell
• Topic: Cancer and Oncology
• Status: Published
• Research group: Experimental Pathology, Malmö
• ISBN/ISSN/Other: ISSN: 1600-0714