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Multi-colour fluorescence imaging in connection with photodynamic therapy of delta-amino levulinic acid (ALA) sensitised skin malignancies

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Author

Summary, in English

Abstract A system for multi-colour fluorescence imaging of tissue is described. The instrument is mainly developed for tissue diagnostics to identify and localise malignant tumours, but might also be useful for real-time monitoring of the therapeutic dose delivered during photodynamic therapy. In vivo examples from various malignant skin lesions following topical δ-amino levulinic acid (ALA) administration are presented. The diagnostic system utilises both characteristics of a fluorescent tumour marker, such as a porphyrin containing substance, and the native tissue autofluorescence to characterise the tissue. A dimensionless function of three or four simultaneously recorded fluorescence intensities is formed and an optimum-contrast image is calculated pixel-by-pixel.

Department/s

Publishing year

1995

Language

English

Pages

134-143

Publication/Series

Bioimaging

Volume

3

Issue

3

Document type

Journal article

Publisher

IOP Publishing

Topic

  • Atom and Molecular Physics and Optics

Keywords

  • tissue diagnostics
  • fluorescence spectroscopy
  • imaging
  • skin cancer
  • photosensitiser
  • ALA

Status

Published

ISBN/ISSN/Other

  • ISSN: 0966-9051