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Toll-Like Receptor 3 Signalling Up-Regulates Expression of the HIV Co-Receptor G-Protein Coupled Receptor 15 on Human CD4(+) T Cells.

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Author

  • Miriam Kiene
  • Bence Rethi
  • Marianne Jansson
  • Stephanie Dillon
  • Eric Lee
  • Rebecka Lantto
  • Cara Wilson
  • Stefan Pöhlmann
  • Francesca Chiodi

Summary, in English

Many HIV-2 and SIV isolates, as well as some HIV-1 strains, can use the orphan 7-transmembrane receptor GPR15 as co-receptor for efficient entry into host cells. GPR15 is expressed on central memory and effector memory CD4(+) T cells in healthy individuals and a subset of these cells is susceptible to HIV-1 and SIV infection. However, it has not been determined whether GPR15 expression is altered in the context of HIV-1 infection.

Publishing year

2014

Language

English

Publication/Series

PLoS ONE

Volume

9

Issue

2

Document type

Journal article

Publisher

Public Library of Science (PLoS)

Topic

  • Microbiology in the medical area

Status

Published

ISBN/ISSN/Other

  • ISSN: 1932-6203