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B cell lymphomas express CX(3)CR1 a non-B cell lineage adhesion molecule.

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Author

  • Ulrika Andreasson
  • Sara Ek
  • Hartmut Merz
  • Richard Rosenquist
  • Niels Andersen
  • Mats Jerkeman
  • Michael Dictor
  • Carl A K Borrebaeck

Summary, in English

To study the differential expression of cell membrane-bound receptors and their potential role in growth and/or survival of the tumor cells, highly purified follicular lymphoma cells were analyzed, using gene expression analysis, and compared to non-malignant B cell populations. Filtering the genome for overexpressed genes coding for cell membrane-bound proteins/receptors resulted in a hit list of 27 identified genes. Among these, we have focused on the aberrant over expression of CX(3)CR1, in different types of B cell lymphoma, as compared to non-malignant B cells. We show that CX(3)CR1, which normally is not expressed on B cells, is expressed both at the mRNA and protein level in several subtypes of lymphoma. CX(3)CR1 has also shown to be involved in the homing to specific tissues that express the ligand, CX(3)CL1, in breast and prostate cancer and may thus be involved in dissemination of lymphoma.

Publishing year

2008

Language

English

Pages

138-145

Publication/Series

Cancer Letters

Volume

259

Issue

2

Document type

Journal article

Publisher

Elsevier

Topic

  • Cancer and Oncology

Status

Published

ISBN/ISSN/Other

  • ISSN: 1872-7980