Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia

Summary, in English

S-(4-hydroxybenzyl)glutathione was isolated as the major principle responsible for the inhibition of the in vitro binding of kainic acid to brain glutamate receptors by water extracts of the plant Gastrodia elata. The affinity (IC50 value) of the compound is slightly lower compared to glutamate and glutathione.

• Author: Maria Andersson; Ola Bergendorff; Mogens Nielsen; Olov Sterner; Robin Witt; Jinglu Ai; Aiping Lu; An Min Wang
• Department/s: Dermatology and Venereology (Lund); Centre for Analysis and Synthesis
• Publishing year: 1995
• Language: English
• Pages: 835-836
• Publication/Series: Phytochemistry
• Volume: 38
• Issue: 4
• Links: http://dx.doi.org/10.1016/0031-9422(94)00771-K
• Document type: Journal article
• Publisher: Elsevier
• Topic: Dermatology and Venereal Diseases
• Status: Published
• ISBN/ISSN/Other: ISSN: 0031-9422