Antibody response to IgA-binding streptococcal M proteins in children with IgA nephropathy.

Summary, in English

BACKGROUND: IgA nephropathy (IgAN), the most common glomerulonephritis worldwide, is characterized by mesangial deposits containing predominantly IgA. IgAN commonly occurs or exacerbates after upper respiratory tract infections such as streptococcal pharyngitis. Certain group A streptococci express M proteins with IgA-binding regions (IgA-BRs). We have previously shown that these IgA-BRs co-localize with mesangial IgA in IgAN. METHODS: Blood samples from patients with IgAN (n = 21) and age-matched controls (n = 83) were assayed by ELISA to detect an IgG antibody response to the IgA-BRs of the M4, M22 and M60 proteins. Antibodies were assayed for each IgA-BR separately and the results were combined. RESULTS: Antibody levels to the IgA-BRs were significantly higher in IgAN patients than controls (P = 0.016), particularly in patients with recent streptococcal infection (P = 0.008). Conclusions. The results suggest that children with IgAN had a previous infection with a streptococcal strain expressing an IgA-binding M protein.

• Author: Roland Schmitt; Gunnar Lindahl; Diana Karpman
• Department/s: Paediatrics (Lund); Division of Medical Microbiology; Pediatric Nephrology
• Publishing year: 2010
• Language: English
• Pages: 1830-1830
• Publication/Series: Pediatric Nephrology
• Volume: 25
• Issue: 9
• Full text: - 1 MB; Download statistics
• Links: http://dx.doi.org/10.1007/s00467-010-1577-z
• Document type: Conference paper: abstract
• Publisher: Springer
• Topic: Pediatrics; Microbiology in the medical area
• Conference name: 15th Congress of the International Pediatric Nephrology Association
• Conference date: 2010-08-29 - 2010-09-02
• Conference place: New York, NY, United States
• Status: Published
• Research group: Pediatric Nephrology
• ISBN/ISSN/Other: ISSN: 1432-198X