The Intratumoral Distribution of Radiolabeled 177Lu-BR96 Monoclonal Antibodies Changes in Relation to Tumor Histology over Time in a Syngeneic Rat Colon Carcinoma Model.

Summary, in English

The therapeutic effect of radioimmunotherapy depends on the distribution of the absorbed dose in relation to viable cancer cells within the tumor, which in turn is a function of the activity distribution. The aim of this study was to investigate the distribution of (177)Lu-DOTA-BR96 monoclonal antibodies targeting the Lewis Y antigen over 7 d using a syngeneic rat model of colon carcinoma.

• Author: Anders Örbom; Sophie Eriksson; Erika Elgström; Tomas G Ohlsson; Rune Nilsson; Jan Tennvall; Sven-Erik Strand
• Department/s: Medical Radiation Physics, Lund; Breastcancer-genetics; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publishing year: 2013
• Language: English
• Pages: 1404-1410
• Publication/Series: Journal of Nuclear Medicine
• Volume: 54
• Issue: 8
• Full text: - 902 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/23804328?dopt=Abstract; http://dx.doi.org/10.2967/jnumed.112.117028
• Document type: Journal article
• Publisher: Society of Nuclear Medicine
• Topic: Radiology, Nuclear Medicine and Medical Imaging
• Status: Published
• ISBN/ISSN/Other: ISSN: 0161-5505