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Imaging in cell-based therapy for neurodegenerative diseases.

På svenska

Author

Summary, in English

Fetal cell transplantation for the treatment of Parkinsonrsquos and Huntingtonrsquos diseases has been developed over the past two decades and is now in early clinical testing phase. Direct assessment of the graftrsquos survival, integration into the host brain and impact on neuronal functions requires advanced in vivo neuroimaging techniques. Owing to its high sensitivity, positron emission tomography is today the most widely used tool to evaluate the viability and function of the transplanted tissue in the brain. Nuclear magnetic resonance techniques are opening new possibilities for imaging neurochemical events in the brain. The ultimate goal will be to use the combination of multiple imaging modalities for complete functional monitoring of the repair processes in the central nervous system.

Publishing year

2005

Language

English

Pages

417-434

Publication/Series

European Journal of Nuclear Medicine and Molecular Imaging

Volume

32

Issue

Suppl 2

Document type

Journal article review

Publisher

Springer

Topic

  • Radiology, Nuclear Medicine and Medical Imaging

Keywords

  • Huntingtonrsquos disease
  • Parkinsonrsquos disease
  • Cell transplantation
  • Positron emission tomography
  • Magnetic resonance imaging

Status

Published

Research group

  • Brain Repair and Imaging in Neural Systems (BRAINS)
  • Neural Plasticity and Repair

ISBN/ISSN/Other

  • ISSN: 1619-7070