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Dacrymenone and VM 3298-2 - New antibiotics with antibacterial and antifungal activity

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Author

Summary, in English

Two new antibiotic metabolites, dacrymenone (1) and VM 3298-2 (2), were isolated from fermentations of a Dacrymyces sp., and their structures were determined by spectroscopic techniques. Dacrymenone (1) is a new eremophilane sesquiterpenoid while VM 3298-2 (2) is a bis-enol ether between methyl pyruvate and 4,6-dihydroxycyclohexan-1,3-dione. Dacrymenone (1) shows weak antibacterial and antifungal activity while VM 3298-2 (2) exhibits cytotoxic and antifungal activities.

Publishing year

2003

Language

English

Pages

541-546

Publication/Series

Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences

Volume

58

Issue

7-8

Document type

Journal article

Publisher

Verlag der Zeitschrift für Naturforschung

Topic

  • Organic Chemistry

Keywords

  • antifungal antibiotic
  • eremophilanes
  • Dacrymyces

Status

Published

ISBN/ISSN/Other

  • ISSN: 0939-5075