Potential Biomarkers for Radiation-Induced Renal Toxicity following 177Lu-Octreotate Administration in Mice.

Summary, in English

C57BL/6N mice were i.v. injected with 0, 30, 60, 90, 120, or 150 MBq 177Lu-octreotate (0, 16, 29, 40, 48, and 54 Gy to the kidneys). At 4, 8, and 12 months after administration, radiation-induced effects were evaluated in relation to (a) global transcriptional variations in kidney tissues, (b) morphological changes in the kidneys, (c) changes in white and red blood cell count as well as blood levels of urea, and (d) changes in renal function using 99mTc-DTPA/99mTc-DMSA scintigraphy.

• Author: Emil Schüler; Maria Larsson; Toshima Z Parris; Martin Johansson; Khalil Helou; Eva Forssell-Aronsson
• Department/s: Clinical pathology, Malmö; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publishing year: 2015
• Language: English
• Publication/Series: PLoS ONE
• Volume: 10
• Issue: 8
• Full text: - 3 MB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26287527?dopt=Abstract; http://dx.doi.org/10.1371/journal.pone.0136204
• Document type: Journal article
• Publisher: Public Library of Science (PLoS)
• Topic: Radiology, Nuclear Medicine and Medical Imaging
• Status: Published
• Research group: Clinical pathology, Malmö
• ISBN/ISSN/Other: ISSN: 1932-6203