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IL-4-deficient mice develop less acute but more chronic relapsing collagen-induced arthritis.

På svenska

Author

  • Lars Svensson
  • Kutty Selva Nandakumar
  • Åsa Johansson
  • Liselotte Jansson
  • Rikard Holmdahl

Summary, in English

Rheumatoid arthritis as well as collagen-induced arthritis (CIA) is thought to involve T cell autoimmunity of the Th1 type and the Th2 cytokine IL-4 has been proposed to play a suppressive role. To exclude a possible skewing role of the mycobacteria used in the complete Freund's adjuvant (CFA) we induced CIA with type II collagen (CII) in incomplete Freund's adjuvant (IFA). Ourresults show that IL-4 deficiency leads to a lesser susceptibility to arthritis and lower B and T cell responses if induced with CII/IFA but not if induced with CII/CFA. In addition, IL-4-deficientmice were less susceptible to arthritis induced with monoclonal anti-CII antibodies. However, mice immunized with CII/IFA later developed a chronic relapsing disease, which was promoted by IL-4 deficiency. We conclude that IL-4 plays different roles depending on the type of adjuvant used and the phase (acute or chronic) of the clinical disease.

Department/s

  • Immunology

Publishing year

2002

Language

English

Pages

2944-2953

Publication/Series

European Journal of Immunology

Volume

32

Issue

10

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Immunology in the medical area

Status

Published

Research group

  • Immunology

ISBN/ISSN/Other

  • ISSN: 1521-4141