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Evolutionary and functional perspectives of the major histocompatibility complex class I antigen-processing machinery

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Author

Summary, in English

Major histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8+ T cells, providing the basis for immune recognition of pathogen-infected cells. Peptides generated mainly by proteasomes in the cytosol are transported into the lumen of the endoplasmic reticulum by transporters associated with antigen processing (TAP). The maturation of MHC class I molecules is controlled by a number of accessory proteins and chaperones that are to a varying degree dedicated to the assembly of MHC class I. Several newly characterised proteins have been demonstrated to play important roles in this process. This review focuses on the functional relationship and evolutionary history of the antigen-processing machinery (APM) components and MHC class I itself. These are of great interest for further elucidating the origin of the immune system and understanding the mechanisms of antigen presentation and immunology in general.

Publishing year

2004

Language

English

Pages

2446-2460

Publication/Series

Cellular and Molecular Life Sciences

Volume

61

Issue

19-20

Document type

Journal article

Publisher

Birkhäuser Verlag

Topic

  • Cell Biology

Status

Published

ISBN/ISSN/Other

  • ISSN: 1420-9071