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Convergence in probiotic Lactobacillus gut-adaptive responses in humans and mice

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Author

  • Maria L. Marco
  • Maaike C. de Vries
  • Michiel Wels
  • Douwe Molenaar
  • Peter Mangell
  • Siv Ahrné
  • Willem M. de Vos
  • Elaine E. Vaughan
  • Michiel Kleerebezem

Summary, in English

Probiotic bacteria provide unique opportunities to study the global responses and molecular mechanisms underlying the effects of gut-associated microorganisms in the human digestive tract. In this study, we show by comparative transcriptome analysis using DNA microarrays that the established probiotic Lactobacillus plantarum 299v specifically adapts its metabolic capacity in the human intestine for carbohydrate acquisition and expression of exopolysaccharide and protein-aceous cell surface compounds. This report constitutes the first application of global gene expression profiling of a commensal microorganism in the human gut. A core L. plantarum transcriptome expressed in the mammalian intestine was also determined through comparisons of L. plantarum 299v activities in humans to those found for L. plantarum WCFS1 in germ-free mice. These results identify the niche-specific adaptations of a dietary microorganism to the intestinal ecosystem and provide novel targets for molecular analysis of microbial-host interactions which affect human health. The ISME Journal (2010) 4, 1481-1484; doi: 10.1038/ismej.2010.61; published online 27 May 2010

Publishing year

2010

Language

English

Pages

1481-1484

Publication/Series

The Isme Journal

Volume

4

Issue

11

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Surgery

Keywords

  • intestine
  • transcript profiling
  • germ-free mice
  • gut microbiota
  • diet
  • in vivo-inducible genes

Status

Published

Research group

  • Surgery

ISBN/ISSN/Other

  • ISSN: 1751-7362