Jejunal pouch reconstruction but not preservation of duodenal passage after total gastrectomy reduces plasma cholecystokinin and pancreatic polypeptide long term in pigs.

Summary, in English

AIM: The long-term effects of reconstructions of the gastrointestinal tract after gastrectomy on plasma levels of gastrointestinal hormones that contribute to food intake controls were evaluated. MATERIALS AND METHODS: Domestic pigs were randomly assigned to sham-surgery or total gastrectomy followed by reconstruction with oesophagojejunostomy on a Roux-en-Y loop (OJRY), jejunal interposition between the oesophagus and the duodenum (OJD), or an oesophagojejunostomy with a jejunal pouch reservoir (J-pouch) on a Roux-en-Y loop. Plasma levels of peptides were analysed by radioimmunoassay (RIA). RESULTS: Ten weeks after surgery, levels of cholecystokinin (CCK) and pancreatic polypeptide (PP) were significantly lowered (79.6% and 67.0%, respectively) in animals with a J-pouch, but not in sham-operated animals or animals with OJRY or OJD, as compared to preoperative levels. The levels of neuropeptide Y (NPY) and peptide YY (PYY) remained unchanged, irrespective of the mode of reconstruction. CONCLUSION: J-pouch, but not preservation of duodenal passage after total gastrectomy, lowers levels of CCK and PP, peptides that reduce food intake.

• Author: Ulrika Smedh; Lars Hansson; Rolf Ekman; Thomas Zilling
• Department/s: Surgery (Lund); Department of Health Sciences
• Publishing year: 2009
• Language: English
• Pages: 93-98
• Publication/Series: In Vivo
• Volume: 23
• Issue: 1
• Links: http://www.ncbi.nlm.nih.gov/pubmed/19368131?dopt=Abstract
• Document type: Journal article
• Publisher: In vivo
• Topic: Cancer and Oncology
• Status: Published
• ISBN/ISSN/Other: ISSN: 0258-851X