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Decorin deficiency leads to impaired angiogenesis in injured mouse cornea

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Author

  • E Schonherr
  • C Sunderkotter
  • L Schaefer
  • S Thanos
  • S Grassel
  • Åke Oldberg
  • RV Iozzo
  • MF Young
  • H Kresse

Summary, in English

Small leucine-rich proteoglycans play important roles in the organization of the extracellular matrix as well as for the regulation of cell behavior; two biological processes that are essential for angiogenesis. We investigated consequences of the targeted ablation of decorin (DCN), biglycan (BGN) and fibromodulin (FMOD) genes on inflammation-induced angiogenesis in the cornea. In wildtype mice, DCN was localized exclusively to the corneal stroma, while FMOD and BGN were more prominently expressed in epithelial cells. Endothelial cells from limbus blood vessels expressed BGN and FMOD, but no DCN. However, after induction of angiogenesis by chemical cauterization, DCN was expressed in the newly formed capillaries, together with BGN and FMOD. Notably, in DCN-deficient mice, the growth of vessels was significantly diminished, whereas it did not significantly change in FMOD- or BGN-deficient animals. Moreover, blood vessels of DCN-deficient mice exhibited a similar expression level of BGN as control mice, while FMOD was increased on day 3 after injury. These results indicate that DCN, in addition to its effects on fibrillogenesis, plays a regulatory role in angiogenesis and that FMOD in endothelial cells may be able to partially substitute for DCN.

Department/s

  • Åke Oldberg´s group

Publishing year

2004

Language

English

Pages

499-508

Publication/Series

Journal of Vascular Research

Volume

41

Issue

6

Document type

Journal article

Publisher

Karger

Topic

  • Cardiac and Cardiovascular Systems

Keywords

  • vascular endothelium
  • extracellular matrix
  • inflammation
  • collagen
  • corneal epithelium

Status

Published

Research group

  • Åke Oldberg´s group

ISBN/ISSN/Other

  • ISSN: 1423-0135