The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

No effect of obstetric complications on basal ganglia volumes in schizophrenia

På svenska

Author

  • Unn Kristin Haukvik
  • Thomas McNeil
  • Ragnar Nesvag
  • Erik Soderman
  • Erik Jonsson
  • Ingrid Agartz

Summary, in English

Background: Heterogeneous findings have been reported in studies of basal ganglia volumes in schizophrenia patients as compared to healthy controls. The basal ganglia contain dopamine receptors that are known to be involved in schizophrenia pathology and to be vulnerable to pre- and perinatal hypoxic insults. Altered volumes of other brain structures (e.g. hippocampus and lateral ventricles) have been reported in schizophrenia patients with a history of obstetric complications (005). This is the first study to explore if there is a relationship between OCs and basal ganglia volume in schizophrenia. Methods: Thorough clinical investigation (including information on medication) of 54 schizophrenia patients and 54 healthy control subjects was undertaken. MR images were obtained on a 1.5T scanner, and volumes of nucleus caudatus, globus pallidum, putamen, and nucleus accumbens were quantified automatically. Information on OCs was blindly collected from original birth records. Results: Unadjusted estimates demonstrated a relationship between increasing number of OCs and larger volume of nucleus accumbens in schizophrenia patients and healthy controls. No statistically significant relationships were found between OCs and the basal ganglia volumes when controlled for intracranial volume, age, and multiple comparisons. There were no effects of typical versus atypical medication on the basal ganglia volumes. The patients with schizophrenia had larger globus pallidum volumes as compared to healthy controls, but there were no case-control differences for accumbens, putamen, or caudate volumes. Conclusion: The present results do not support the hypothesis that OCs are related to alterations in basal ganglia volume in chronic schizophrenia. (C) 2010 Elsevier Inc. All rights reserved.

Publishing year

2010

Language

English

Pages

619-623

Publication/Series

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volume

34

Issue

4

Document type

Journal article review

Publisher

Elsevier

Topic

  • Environmental Health and Occupational Health

Keywords

  • Schizophrenia
  • complications
  • Obstetric
  • Neurodevelopment
  • MRI
  • Basal ganglia
  • Dopamine

Status

Published

ISBN/ISSN/Other

  • ISSN: 0278-5846