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Synthesis of water-dispersible photoluminescent silicon nanoparticles and their use in biological fluorescent imaging

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Author

  • Qi Wang
  • Hongjun Ni
  • Annette Pietzsch
  • Franz Hennies
  • Yongping Bao
  • Yimin Chao

Summary, in English

Water-dispersible silicon nanoparticles (Si-NPs) are desirable for applications in biological techniques. A simplified method to synthesize such particles is reported here. The resulting Si-NPs are water-dispersible and luminescent. Under the excitation of UV light, the Si-NPs emit strong red light with a peak maximum at 606 nm and a quantum yield of 6%. They are highly stable, and remain so over several weeks. Fourier Transform Infrared (FTIR) spectroscopy shows a visible Si-CH2 scissoring vibration mode. Furthermore, the surface chemical bondings were confirmed by X-ray photoelectron spectroscopy (XPS). In the Si2p and C1s core levels, Si-C components are observed. The diameters of the synthesized Si-NPS as measured by atomic force microscope (AFM) are approximately 5 nm. Furthermore, the nanoparticles can be taken up by cultured cells. Fluorescence images of Si-NPs within MCF-7 human breast cancer cells show they are distributed throughout the cell tissue.

Department/s

Publishing year

2011

Language

English

Pages

405-413

Publication/Series

Journal of Nanoparticle Research

Volume

13

Issue

1

Document type

Journal article

Publisher

Springer

Topic

  • Nano Technology

Keywords

  • Silicon nanoparticles
  • Photoluminescence
  • X-ray photoelectron
  • spectroscopy
  • Bio-imaging
  • Nanobiology
  • Nanomedicine

Status

Published

ISBN/ISSN/Other

  • ISSN: 1572-896X