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Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases.

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Author

Summary, in English

The related Axl, Sky and Mer receptor tyrosine kinases (RTKs) are increasingly being implicated in a host of discrete cellular responses including cell survival, proliferation, migration and phagocytosis. Furthermore, their ligands Gas6 and protein S are characteristically dependent on vitamin K for expression of their functions. The Gas6/Axl system is implicated in several types of human cancer as well as inflammatory, autoimmune, vascular and kidney diseases. Each member of the Axl RTK subfamily possesses distinct expression profiles as well as discrete functions. In this article, we review the knowledge so far on the intracellular signalling interactions and pathways concerning each of the Axl RTKs. In this way, we hope to gain a greater understanding of the mechanisms that set each of them apart, and that relay their associated functions. (c) 2006 Elsevier Ltd. All rights reserved.

Publishing year

2006

Language

English

Pages

295-304

Publication/Series

Cytokine & Growth Factor Reviews

Volume

17

Issue

4

Document type

Journal article review

Publisher

Elsevier

Topic

  • Medicinal Chemistry

Keywords

  • vitamin K
  • cell survival
  • receptor tyrosine kinase
  • Axl
  • Gas6

Status

Published

Research group

  • Clinical Chemistry, Malmö

ISBN/ISSN/Other

  • ISSN: 1359-6101