Radiolabeled antibodies in prostate cancer: A case study showing the effect of host immunity on antibody bio-distribution.

Summary, in English

Human tumors xenografted in immunodeficient mice are crucial models in nuclear medicine to evaluate the effectiveness of candidate diagnostic and therapeutic compounds. However, little attention has been focused on the biological profile of the host model and its potential effects on the bio-distribution and tumor targeting of the tracer compound under study. We specifically investigated the dissimilarity in bio-distribution of (111)In-DTPA-5A10, which targets free prostate specific antigen (fPSA), in two animal models.

• Author: Oskar Vilhelmsson Timmermand; Elmer Santos; Daniel L J Thorek; Susan Evans Axelsson; Anders Bjartell; Hans Lilja; Steven M Larson; Sven-Erik Strand; Thuy Tran; David Ulmert
• Department/s: Medical Radiation Physics, Lund; Urological cancer, Malmö; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation; Clinical Chemistry, Malmö; Lund University Bioimaging Center; EpiHealth: Epidemiology for Health
• Publishing year: 2015
• Language: English
• Pages: 375-380
• Publication/Series: Nuclear Medicine and Biology
• Volume: 42
• Issue: 4
• Links: http://www.ncbi.nlm.nih.gov/pubmed/25577038?dopt=Abstract; http://dx.doi.org/10.1016/j.nucmedbio.2014.12.012
• Document type: Journal article
• Publisher: Elsevier
• Topic: Radiology, Nuclear Medicine and Medical Imaging
• Status: Published
• Research group: Urological cancer, Malmö; Clinical Chemistry, Malmö
• ISBN/ISSN/Other: ISSN: 1872-9614