The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Synthesis of C-1 indol-3-yl substituted tetrahydroisoquinoline derivatives via a Pictet-Spengler approach

På svenska

Author

  • Rikard Larsson
  • Narda Blanco
  • Martin H Johansson
  • Olov Sterner

Summary, in English

A protocol for the diastereoselective synthesis of C-1 indol-3-yl substituted tetrahydroisoquinoline derivatives via Pictet-Spengler condensation with L-DOPA or L-DOPA derivatives and 1H-indole-3-carbaldehydes is presented. The protocol is used for the successful synthesis of several tetrahydroisoquinolines as well as diketopiperazine fused analogues. (C) 2012 Elsevier Ltd. All rights reserved.

Publishing year

2012

Language

English

Pages

4966-4970

Publication/Series

Tetrahedron Letters

Volume

53

Issue

37

Document type

Journal article

Publisher

Elsevier

Topic

  • Chemical Sciences

Keywords

  • Pictet-Spengler condensation
  • L-DOPA
  • 1H-Indole-3-carbaldehydes
  • C-1
  • Indolyl tetrahydroisoquinolines
  • Diketopiperazine fused
  • tetrahydroisoquinolines

Status

Published

ISBN/ISSN/Other

  • ISSN: 0040-4039