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Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale

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Author

  • Pedro Aqueveque
  • Carlos Leonardo Cespedes
  • Jose Becerra
  • Marcelo Davila
  • Olov Sterner

Summary, in English

Liquid fermentations of the fungus Stereum rameale (No 2511) yielded extracts with antibacterial -activity. The antibacterial activity reached its peak after 216 h of stirring. Bioassay-guided fractionation methods were employed for the isolation of the bioactive metabolites. Three known compounds were identified: MS-3 (1), vibralactone (2) and vibralactone B (3). The three compounds showed antibacterial activity as a function of their concentration. Minimal bactericidal concentrations (MBC) of compound 1 against Gram-positive bacteria were as follows: Bacillus cereus (50 mu g/mL), Bacillus subtilis (10 mu g/mL) and Staphylococcus aureus (100 mu g/mL). Compounds 2 and 3 were active only against Gram-negative bacteria. The MBC of compound 2 against Escherichia coli was 200 mu g/mL. Compound 3 inhibited significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 mu g/mL, respectively.

Publishing year

2015

Language

English

Pages

97-102

Publication/Series

Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences

Volume

70

Issue

3-4

Document type

Journal article

Publisher

Verlag der Zeitschrift für Naturforschung

Topic

  • Biochemistry and Molecular Biology

Keywords

  • antibacterial activity
  • MIC
  • MS-3
  • Stereum rameale
  • vibralactone

Status

Published

ISBN/ISSN/Other

  • ISSN: 0939-5075