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Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling.

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Author

Summary, in English

SRC-like adaptor protein (SLAP) is an adaptor protein structurally similar to the SRC family protein kinases. Like SRC, SLAP contains an SH3 domain followed by an SH2 domain but the kinase domain has been replaced by a unique C-terminal region. SLAP is expressed in a variety of cell types. Current studies suggest that it regulates signaling of various cell surface receptors including the B cell receptor, the T cell receptor, cytokine receptors and receptor tyrosine kinases which are important regulator of immune and cancer cell signaling. SLAP targets receptors, or its associated components, by recruiting the ubiquitin machinery and thereby destabilizing signaling. SLAP directs receptors to ubiquitination-mediated degradation and controls receptors turnover as well as signaling. Thus, SLAP appears to be an important component in regulating signal transduction required for immune and malignant cells.

Department/s

Publishing year

2015

Language

English

Pages

2535-2544

Publication/Series

Cellular and Molecular Life Sciences

Volume

72

Issue

13

Document type

Journal article review

Publisher

Birkhäuser Verlag

Topic

  • Cell Biology

Status

Published

ISBN/ISSN/Other

  • ISSN: 1420-9071