Optimization of breast tomosynthesis: Computer simulations of image acquisition and glandular dose
Optimering av brösttomosyntes : Datorsimuleringar av bildinsamling och bröstkörteldos
Author
Summary, in English
In this thesis, a simulation procedure was developed for the optimization of image acquisition and estimation of individual glandular dose in BT. The procedure was shown to be useful in generating BT images with realistic sharpness, though with higher image noise and contrast than experimentally acquired images (Paper I). The procedure was used to investigate the influence of angular range, distribution of projection images, and dose distribution on simulated microcalcifications in reconstructed BT volumes. Image acquisitions with very high central dose yielded significantly lower visibility than acquisitions with more uniform dose distributions, and the depth resolution increased with wider angular range (Paper II).
A method for localizing dense tissue from reconstructed BT volumes was verified using the simulation procedure (Paper III). A prototype software program was used for automatic and objective estimation of breast density in BT, with similar performance as DM (Paper IV). Using software breast phantoms recreated from reconstructed BT volumes, the glandular dose could be estimated with good overall accuracy for breast phantoms with different amounts and distributions of dense tissue (Paper V).
The developed simulation procedure has been a useful tool for optimizing acquisition parameters and estimating glandular dose in BT. The procedure could potentially be developed for further evaluation of the imaging chain and estimation of individual glandular dose in human cases.
Department/s
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
- Medical Radiation Physics, Malmö
Publishing year
2018
Language
English
Publication/Series
Lund University, Faculty of Medicine Doctoral Dissertation Series
Volume
2018
Issue
71
Full text
Document type
Dissertation
Publisher
Lund University: Faculty of Medicine
Topic
- Medical and Health Sciences
Keywords
- breast tomosynthesis
- Monte Carlo simulation
- acquisition parameters
- software breast phantom
- microcalcifications
- breast density
- glandular dose
- glandular distribution
Status
Published
Project
- Optimization of breast tomosynthesis: Computer simulations of image acquisition and glandular dose
Research group
- Medical Radiation Physics, Malmö
ISBN/ISSN/Other
- ISSN: 1652-8220
- ISBN: 978-91-7619-637-3
Defence date
5 June 2018
Defence time
09:00
Defence place
CRC, rum 93-09-002, Jan Waldenströms gata 35, Skånes Universitetssjukhus i Malmö
Opponent
- Susan Astley (PhD)