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Identification of a novel protease inhibitor gene that is highly expressed in the prostate.

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Author

Summary, in English

A novel gene was identified 52 kb upstream of the gene encoding the protease inhibitor elafin (PI3) on human chromosome 20q12-13.1. The transcript of the new gene, denoted huWAP2, was characterized by rapid amplification of cDNA ends and DNA sequencing. The size is 774 bp and it gives rise to a polypeptide of 111 amino acid residues that is homologous to elafin and similar WAP-type protease inhibitors. By RT-PCR it was shown that the gene is highly expressed in prostate, skin, lung, and esophagus.

Publishing year

2002

Language

English

Pages

452-456

Publication/Series

Biochemical and Biophysical Research Communications

Volume

290

Issue

1

Document type

Journal article

Publisher

Elsevier

Topic

  • Biological Sciences

Keywords

  • Male
  • Molecular Sequence Data
  • Prostate : metabolism
  • Protease Inhibitors : chemistry
  • Protein Structure Tertiary
  • Reverse Transcriptase Polymerase Chain Reaction
  • Proteins : biosynthesis : chemistry : genetics
  • Sequence Analysis DNA
  • Sequence Homology Amino Acid
  • Sequence Homology Nucleic Acid
  • Tissue Distribution
  • Support Non-U.S. Gov't
  • Exons
  • Human
  • DNA Complementary : metabolism
  • Chromosomes Human Pair 20
  • Base Sequence
  • Amino Acid Sequence

Status

Published

Research group

  • Clinical Chemistry, Malmö

ISBN/ISSN/Other

  • ISSN: 1090-2104