The 5-hydroxytryptamine stimulated formation of inositol phosphate is inhibited in platelets from alcoholics

Summary, in English

The accumulation of inositol monophosphate (IP1) was measured after stimulation of 5-hydroxytryptamine2 (5-HT2) receptors on platelets from alcoholics and healthy controls. In controls, 5-HT induced a dose-dependent response with an EC50 = 2 x 10(-6) M and a maximal response at 10(-5) M. Ritanserin, a selective 5-HT2 antagonist, markedly reduced the accumulation. The IP1 formation after stimulation by 10(-5) M 5-HT was significantly impaired in platelets from alcoholics as compared to controls. This study indicates that the 5-HT2 receptor function is inhibited in alcoholics. It also illustrates the possibility of using IP1 formation in peripheral cells as a mean of studying receptor function in disease.

• Author: Per Simonsson; Christer Alling
• Department/s: Clinical Chemistry, Malmö; Division of Clinical Chemistry and Pharmacology
• Publishing year: 1988
• Language: English
• Pages: 385-391
• Publication/Series: Life Sciences
• Volume: 42
• Issue: 4
• Links: http://dx.doi.org/10.1016/0024-3205(88)90076-8
• Document type: Journal article
• Publisher: Elsevier
• Topic: Medicinal Chemistry
• Status: Published
• Research group: Clinical Chemistry, Malmö
• ISBN/ISSN/Other: ISSN: 1879-0631