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Graphene coatings for chemotherapy: avoiding silver-mediated degradation

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Author

  • Federico Mazzola
  • Thuat Trinh
  • Simon Cooil
  • Elise Ramleth Ostli
  • Kristin Hoydalsvik
  • Eirik Torbjorn Bakken Skjonsfjell
  • Signe Kjelstrup
  • Alexei Preobrajenski
  • Attilio A. Cafolla
  • D. Andrew Evans
  • Dag W. Breiby
  • Justin W. Wells
Show all

Summary, in English

Chemotherapy treatment usually involves the delivery of fluorouracil (5-Fu) together with other drugs through central venous catheters. Catheters and their connectors are increasingly treated with silver or argentic alloys/compounds. Complications arising from broken catheters are common, leading to additional suffering for patients and increased medical costs. Here, we uncover a likely cause of such failure through a study of the surface chemistry relevant to chemotherapy drug delivery, i.e. between 5-Fu and silver. We show that silver catalytically decomposes 5-Fu, compromising the efficacy of the chemotherapy treatment. Furthermore, HF is released as a product, which will be damaging to both patient and catheter. We demonstrate that graphene surfaces inhibit this undesirable reaction and would offer superior performance as nanoscale coatings in cancer treatment applications.

Department/s

Publishing year

2015

Language

English

Publication/Series

2D Materials

Volume

2

Issue

2

Document type

Journal article

Publisher

IOP Publishing

Topic

  • Materials Chemistry

Keywords

  • photoemission
  • surface chemistry
  • fluorouracil
  • chemotherapy
  • graphene

Status

Published

ISBN/ISSN/Other

  • ISSN: 2053-1583