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Analysis of methylhexahydrophthalic acid in human urine

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Author

Summary, in English

A method for analysis of urinary methylhexahydrophthalic acid (MHHP acid), a metabolite of the highly sensitising methylhexahydrophthalic anhydride, is described. The method is based on a double liquid-solid extraction of the MHHP acid from urine, esterification with methanol and boron trifluoride catalysis, and analysis with gas chromatography-mass spectrometry in the electron impact mode. The detection limit was 3 ng mL–1 and the precision between 2 and 5% in the range 34 to 340 ng mL–1. The method gave similar results compared to another method. Urine stored for five years at –20°C lost between 38 and 86% of the MHHP acid (range 16–85 ng mL–1).

Publishing year

1996

Language

English

Pages

668-670

Publication/Series

Chromatographia

Volume

43

Issue

11-12

Document type

Journal article

Publisher

Vieweg Verlag

Topic

  • Environmental Health and Occupational Health

Keywords

  • Industrial hygiene
  • Biological monitoring
  • Methylhexahydrophthalic acid
  • Gas chromatography-mass spectrometry

Status

Published

ISBN/ISSN/Other

  • ISSN: 0009-5893