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Cytogenetic abnormalities and clonal evolution in an adult hepatoblastoma

På svenska

Author

Summary, in English

Hepatoblastomas usually occur in children < 3 years of age, and only occasional adult cases have been described. To date, 20 cytogenetically abnormal childhood hepatoblastomas have been reported. Karyotypic investigations have shown that most hepatoblastomas are diploid or hyperdiploid, often displaying trisomies for chromosomes 2 and 20. We have cytogenetically investigated an adult hepatoblastoma for which no previous karyotypic data exist. A hypertriploid stemline with multiple numerical and structural chromosomal aberrations, including +2 and +20, was found. In addition, the tumor displayed extensive clonal evolution with 11 subclones. Although the tumor thus displayed some chromosomal abnormalities commonly observed in childhood tumors, providing further support for the importance of these abnormalities in the development of hepatoblastoma, the level of genomic complexity seen in the present case has never been described in childhood hepatoblastomas and may suggest a different etiology or pathogenesis.

Publishing year

1997

Language

English

Pages

6-1381

Publication/Series

American Journal of Surgical Pathology

Volume

21

Issue

11

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Medical and Health Sciences

Keywords

  • Keratins/analysis
  • Karyotyping
  • Immunohistochemistry
  • Humans
  • Hepatoblastoma/chemistry/ genetics/ pathology
  • Pair 1
  • Human
  • Chromosomes
  • Chromosome Disorders
  • Aged
  • Chromosome Aberrations
  • Liver Neoplasms/chemistry/ genetics/ pathology
  • Male
  • Tumor Markers
  • Biological/analysis

Status

Published

ISBN/ISSN/Other

  • ISSN: 1532-0979