Trichloroethylene: Effects on body and organ weights in mice, rats and gerbils
Author
Summary, in English
The influence of continuous inhalation of 150 ppm trichloroethylene (TCE) on body, liver, spleen, and kidney weights in rats, mice, and mongolian gerbils was tested.
An age dependent decrease in body weight gain was observed in female rats exposed to TCE. All 3 spcies showed liver enlargement caused by the exposure. The effect was much more pronounced in mice, in which the increase was 60–80%, than in rats and gerbils where it was only 20–30%. After the end of the TCE-exposure the liver weights of the mice decreased rapidly. After 5 days of rehabilitation to the weight was only 10–20% higher than that of the controls. This difference persisted for at least 25 days. The spleen weight appeared unaffected or somewhat smaller in TCE-exposed animals of all species. An increased kidney weight (15%) was observed in TCE-exposed gerbils. This effect was less pronounced in mice and rats.
Effects on the liver have earlier been seen only after exposure to concentrations much higher than that used in the present study. This difference is results in proposed to be due to the different schedules used for the exposure.
An age dependent decrease in body weight gain was observed in female rats exposed to TCE. All 3 spcies showed liver enlargement caused by the exposure. The effect was much more pronounced in mice, in which the increase was 60–80%, than in rats and gerbils where it was only 20–30%. After the end of the TCE-exposure the liver weights of the mice decreased rapidly. After 5 days of rehabilitation to the weight was only 10–20% higher than that of the controls. This difference persisted for at least 25 days. The spleen weight appeared unaffected or somewhat smaller in TCE-exposed animals of all species. An increased kidney weight (15%) was observed in TCE-exposed gerbils. This effect was less pronounced in mice and rats.
Effects on the liver have earlier been seen only after exposure to concentrations much higher than that used in the present study. This difference is results in proposed to be due to the different schedules used for the exposure.
Department/s
Publishing year
1981
Language
English
Pages
105-115
Publication/Series
Toxicology
Volume
21
Issue
2
Document type
Journal article
Publisher
Elsevier
Topic
- Probability Theory and Statistics
Status
Published
ISBN/ISSN/Other
- ISSN: 0300-483X