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The role of p-c-Jun in survival and outgrowth of developing sensory neurons

På svenska

Author

  • Charlotta Lindwall
  • Martin Kanje

Summary, in English

c-jun activation has been implicated not only in neuronal apoptosis, but also in survival and regeneration. This Janus facet of c-Jun activation could be related to neuronal cell type or to the developmental stage of the neuron. We investigated c-Jun activation in E18 sensory neurons. Cultures of rat dorsal root ganglia neurons were maintained with or without the addition of nerve growth factor or the c-Jun N-terminal kinase inhibitor, (D)-JNKII. Few dorsal root ganglia neurons survived nerve growth factor deprivation, whereas neurons supplied with nerve growth factor survived and exhibited extensive axonal outgrowth. Activated c-Jun was present in the nuclei of neurons with regenerating axons, but not in apoptotic neurons. c-Jun N-terminal kinase inhibition reduced the number of p-c-Jun immunoreactive and regenerating neurons, and increased cell death. Thus, activation of c-Jun seems to be required for survival and regeneration of developing sensory neurons.

Publishing year

2005

Language

English

Pages

1655-1659

Publication/Series

NeuroReport

Volume

16

Issue

15

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Neurosciences

Keywords

  • nerve growth
  • dorsal root ganglia
  • development
  • c-Jun
  • (D)-JNKII
  • rat
  • factor

Status

Published

ISBN/ISSN/Other

  • ISSN: 1473-558X