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Alternatively folded proteins with unexpected beneficial functions

På svenska

Author

  • Soyoung Min
  • James Meehan
  • Louise M. Sullivan
  • Nial P. Harte
  • Yongjing Xie
  • Gavin P. Davey
  • Catharina Svanborg
  • Andre Brodkorb
  • Ken Mok

Summary, in English

HAMLET (human alpha-lactalbumin made lethal to tumour cells) and its related partially unfolded protein-fatty acid complexes are novel biomolecular nanoparticles that possess relatively selective cytotoxic activities towards tumour cells. One of the key characteristics is the requirement for the protein to be partially unfolded, hence endowing native proteins with additional functions in the alternatively folded states. Beginning with the history of its discovery and development, the cellular targets that appear to be strongly correlated with tumour cell death are introduced in the present article.

Publishing year

2012

Language

English

Pages

746-751

Publication/Series

Biochemical Society Transactions

Volume

40

Document type

Journal article

Publisher

Biochemical Society

Topic

  • Biochemistry and Molecular Biology

Keywords

  • alternatively folded protein
  • bovine alpha-lactalbumin made lethal to
  • tumour cells (BAMLET)
  • equine lysozyme with oleic acid (ELOA)
  • human
  • alpha-lactalbumin made lethal to tumour cells (HAMLET)
  • multimeric
  • alpha-lactalbumin (MAL).

Status

Published

ISBN/ISSN/Other

  • ISSN: 0300-5127