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Pooled analysis and meta-analysis of the glutathione S-transferase P1 lle 105Val polymorphism and bladder cancer: A HuGE-GSEC review

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Author

  • Eliane Kellen
  • Marjolein Hemelt
  • Karin Broberg Palmgren
  • Klaus Golka
  • Vessela Nedelcheva Kristensen
  • Rayjean J. Hung
  • Giuseppe Matullo
  • Rama D. Mittal
  • Stefano Porru
  • Andrew Povey
  • Wolfgang A. Schulz
  • Jianhua Shen
  • Frank Buntinx
  • Maurice P. Zeegers
  • Emanuela Taioli
Show all

Summary, in English

The glutathione S-transferase P1 genotype (GSTP1) is involved in the inactivation of cigarette smoke carcinogens, and sequence variation in the gene may alter bladder cancer susceptibility. To examine the association between GSTP1lle 105Val and bladder cancer, the authors undertook a meta- and pooled analysis. Summary crude and adjusted odds ratios and corresponding 95% confidence intervals were pooled by using a random-effects model. In the meta-analysis (16 studies, 4,273 cases and 5,081 controls), the unadjusted summary odds ratios for GSTP1 lle/Val and Val/Val compared with GSTP1 lle/lle were 1.54 (95% confidence interval: 1.21,1.99; p < 0.001) and 2.17 (95% confidence interval: 1.27, 3.71; p = 0.005). The association appeared to be the strongest in Asian countries. When the analysis was limited to European descendents (nine studies), the summary odds ratio decreased (odds ratio = 1.24, 95% confidence interval: 1.00, 1.52) (Q = 17.50; p = 0.02). All relevant data previously contributed to the International Study on Genetic Susceptibility to Environmental Carcinogens were pooled (eight studies, 1,305 cases and 1,558 controls). The summary odds ratios were similar to the ones from the meta-analysis. Case-only analyses did not detect an interaction between the GSTP1 genotype and smoking status (never/ever). GSTP1 lle 105Val appears to be associated with a modest increase in the risk of bladder cancer.

Publishing year

2007

Language

English

Pages

1221-1230

Publication/Series

American Journal of Epidemiology

Volume

165

Issue

11

Document type

Journal article review

Publisher

Oxford University Press

Topic

  • Public Health, Global Health, Social Medicine and Epidemiology

Keywords

  • urinary bladder neoplasms
  • GSTP1
  • meta-analysis

Status

Published

ISBN/ISSN/Other

  • ISSN: 0002-9262