Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant-174GC with circulating glucose levels, interleukin-6 levels, and body mass index
Author
Summary, in English
Background. Several studies have investigated associations between the -174GC single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results. Aims. This joint analysis aimed to clarify whether IL6 -174GC was associated with glucose and circulating interleukin-6 concentrations as well as body mass index (BMI). Methods. Individual-level data from all studies of the IL6-T2DM consortium on Caucasian subjects with available BMI were collected. As study-specific estimates did not show heterogeneity (P0.1), they were combined by using the inverse-variance fixed-effect model. Results. The main analysis included 9440, 7398, 24,117, or 5659 non-diabetic and manifest T2DM subjects for fasting glucose, 2-hour glucose, BMI, or circulating interleukin-6 levels, respectively. IL6 -174 C-allele carriers had significantly lower fasting glucose (-0.091 mmol/L, P=0.014). There was no evidence for association between IL6 -174GC and BMI or interleukin-6 levels, except in some subgroups. Conclusions. Our data suggest that C-allele carriers of the IL6 -174GC polymorphism have lower fasting glucose levels on average, which substantiates previous findings of decreased T2DM risk of these subjects.
Department/s
Publishing year
2009
Language
English
Pages
128-138
Publication/Series
Annals of Medicine
Volume
41
Issue
2
Document type
Journal article
Publisher
Taylor & Francis
Topic
- Endocrinology and Diabetes
Keywords
- meta-analysis
- molecular epidemiology
- single nucleotide polymorphism
- intermediate phenotype
- interleukin-6
- inflammation mediators
- genes
- diabetes mellitus type 2
- Blood glucose
- body mass index
Status
Published
Research group
- Genomics, Diabetes and Endocrinology
ISBN/ISSN/Other
- ISSN: 1365-2060