Platelet-derived S100A8/A9 and cardiovascular disease in systemic lupus erythematosus.

Summary, in English

S100A8/A9, a pro-inflammatory and pro-thrombotic protein complex, is increased in several diseases and high levels predispose to cardiovascular disease (CVD). Recently, platelet S100A8/A9 synthesis was described in mouse and humans in relation to CVD. However, the role of platelet S100A8/A9 in systemic lupus erythematosus (SLE), a disease with markedly increased cardiovascular morbidity, as well as the exact platelet distribution of the S100A8/A9 proteins has not been investigated.

• Author: Christian Lood; Helena Tydén; Birgitta Gullstrand; Andreas Jönsen; Eva Källberg; Matthias Mörgelin; Robin Kahn; Iva Gunnarsson; Tomas Leanderson; Fredrik Ivars; Elisabet Svenungsson; Anders Bengtsson
• Department/s: Rheumatology; Immunology; Infection Medicine (BMC); Paediatrics (Lund); EpiHealth: Epidemiology for Health
• Publishing year: 2016-03-04
• Language: English
• Publication/Series: Arthritis & Rheumatology
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26946461?dopt=Abstract; http://dx.doi.org/10.1002/art.39656
• Document type: Journal article
• Publisher: John Wiley & Sons Inc.
• Topic: Cell and Molecular Biology
• Status: Published
• Research group: Immunology
• ISBN/ISSN/Other: ISSN: 2326-5205