Group G streptococci mediate fibrinogendependent platelet aggregation leading to transient entrapment in platelet aggregates
Author
Summary, in English
Platelets have been reported to become activated in response to bacteria and this is proposed to contribute to the acute response to bacterial infection. In the present study, we investigated platelet aggregation in response to group G streptococci (GGS) in vitro in healthy human donors and in vivo in a mouse model of streptococcal sepsis. Platelet aggregation by GGS was dependent on the bacterial surface protein FOG and engagement of the platelet fibrinogen receptor; however, it was independent of IgG and the platelet Fc receptor. Platelets exerted no antibacterial effects on the bacteria, and aggregates formed were markedly unstable, allowing bacteria to rapidly return to the plasma and grow post-aggregation. Thrombocytopenia and platelet activation occurred during invasive infection with GGS, and platelets were demonstrated to contribute to bacterial dissemination during infection. These findings reveal an important role for bacteria–platelet interactions during the pathogenesis of streptococcal infection.
Department/s
Publishing year
2016-01-01
Language
English
Pages
117-126
Publication/Series
Microbiology
Volume
162
Issue
1
Document type
Journal article
Publisher
MAIK Nauka/Interperiodica
Topic
- Infectious Medicine
Keywords
- G streptococci
- platelet aggregation
Status
Published
Research group
- Immunomodulatory effects of platelets during inflammation and infection
- SEBRA Sepsis and Bacterial Resistance Alliance
ISBN/ISSN/Other
- ISSN: 1350-0872