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Blood perfusion studies on basal cell carcinomas in conjunction with photodynamic- and cryo therapy employing laser-Doppler imaging

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Author

Summary, in English

Superficial blood perfusion mas monitored using laser-Doppler perfusion imaging in connection with a phase LII clinical trial comparing photodynamic therapy, utilizing topically applied aminoleuvlinic acid, with cryotherapy of basal cell, carcinomas. A total of 526 images mere recorded before and immediately after the treatment and during the follow-up period. Before treatment, the lesions exhibited a blood perfusion 3+/-2 times that in normal tissue. Both treatment modalities induced an increased blood perfusion inside the lesions, which slowly approached normal values in conjunction with successful treatments. The blood perfusion in successfully treated lesions approached normal values 2 months after photodynamic therapy, and about 1 year after cryotherapy, The tissue perfusion in recurrent lesions did not decrease to normal values after the treatment, suggesting that the laser-Doppler perfusion imaging technique can be used to follow the healing process and discover possible persistent tumour growth.

Publishing year

2000

Language

English

Pages

19-23

Publication/Series

Acta Dermato-Venereologica

Volume

80

Issue

1

Document type

Journal article

Publisher

Medical Journals Limited

Topic

  • Dermatology and Venereal Diseases

Keywords

  • laser-Doppler flowmetry
  • aminolevulinic acid
  • photochemotherapy
  • basal cell
  • carcinoma
  • perfusion
  • regional

Status

Published

ISBN/ISSN/Other

  • ISSN: 1651-2057