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Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation.

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Author

Summary, in English

Exacerbations of asthma caused by respiratory viral infections are serious conditions in need of novel treatment. To this end animal models of asthma exacerbations are warranted. We have shown that dsRNA challenges or rhinoviral infection produce exacerbation effects in mice with ovalbumin (OVA)-induced allergic asthma. However, house dust mite (HDM) is a more human asthma-relevant allergen than OVA. We thus hypothesised that dsRNA challenges in mice with HDM-induced experimental asthma would produce important translational features of asthma exacerbations.

Publishing year

2016

Language

English

Publication/Series

Journal of Translational Medicine

Volume

14

Issue

1

Document type

Journal article

Publisher

BioMed Central (BMC)

Topic

  • Respiratory Medicine and Allergy

Status

Published

Research group

  • Respiratory Immunopharmacology

ISBN/ISSN/Other

  • ISSN: 1479-5876