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Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis.

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Author

  • Kaixin Zhou
  • Louise Donnelly
  • Jian Yang
  • Miaoxin Li
  • Harshal Deshmukh
  • Natalie Van Zuydam
  • Emma Ahlqvist
  • Chris C Spencer
  • Leif Groop
  • Andrew D Morris
  • Helen M Colhoun
  • Pak C Sham
  • Mark I McCarthy
  • Colin N A Palmer
  • Ewan R Pearson
Show all

Summary, in English

Metformin is a first-line oral agent used in the treatment of type 2 diabetes, but glycaemic response to this drug is highly variable. Understanding the genetic contribution to metformin response might increase the possibility of personalising metformin treatment. We aimed to establish the heritability of glycaemic response to metformin using the genome-wide complex trait analysis (GCTA) method.

Publishing year

2014

Language

English

Pages

481-487

Publication/Series

The Lancet Diabetes & Endocrinology

Volume

2

Issue

6

Document type

Journal article

Publisher

Elsevier

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 2213-8595