Oral and Oropharyngeal Cancer - Aspects on Epidemiology and Prognostic Markers
Author
Summary, in English
This thesis aimed to investigate the epidemiological changes for tongue cancer in the Nordic countries and to compare some possible predictive factors for OOPHSCC. During the period 1960-1994, an incidence increase in SCC of the mobile tongue in all ages, except for women aged 65-79, was observed. Data including site and histology was obtained from the national cancer registries. The increase was most pronounced in young adults (20-39 years), with a five-fold increase in men and a six-fold increase in women. Young adults had a significantly better crude, as well as relative, survival compared to older patients. In a follow-up study, the incidence trends were studied, extending the study period by 14 years, extracting data from the NORDCAN registry. The incidence increase continued for all ages, except for in young adult men.
In a consecutive series of 128 OOPHSCC, no difference in five year survival was found between patients with HPV positive and HPV negative tumours. Sample collection method was by cotton tipped swab and mouth wash (SMC). When 91 patients from the same study population were analysed, instead using formalin fixed paraffin embedded tissue from their diagnostic biopsies (FFPE), again no survival difference was found. The rate of inconsistent results between SMC and FFPE was 27%.
In a set of 55 OOPHSCC, alpha B-crystallin was found to be a strong independent prognostic marker for poor prognosis in oral SCC, but not in oropharyngeal SCC. The findings highlight the fact that more and more differences between oral and oropharyngeal SCC are being revealed.
Department/s
Publishing year
2014
Language
English
Publication/Series
Lund University Faculty of Medicine Doctoral Dissertation Series
Volume
2014:88
Full text
Document type
Dissertation
Publisher
Lund University, Faculty of Medicine, Otorhinolaryngology (Lund)
Topic
- Otorhinolaryngology
Keywords
- Tongue cancer
- SCC
- oral cancer
- oropharyngeal cancer
- survival
- incidence
- HPV
- human papillomavirus
- alpha B-crystallin
- sample collection methods
- prognostic factor
Status
Published
Supervisor
ISBN/ISSN/Other
- ISSN: 1652-8220
- ISBN: 978-91-7619-017-3
Defence date
3 October 2014
Defence time
09:15
Defence place
The auditorium, Kulturen, Lund, Sweden
Opponent
- Michiel van den Brekel (Professor)