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Evaluation of two pairs of chiral stationary phases: Effects from the length of the achiral spacers

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Author

Summary, in English

Two pairs of chiral stationary phases (CSPs) with different C-2-symmetric central parts were prepared and evaluated by chromatography of a series of structurally different racemates. Within each pair, the selectors on which the CSPs are based had different lengths of their achiral spacers. The CSPs based on selectors with short spacers showed higher enantioselectivity than the phases incorporating long spacers. On one pair of the phases, a study of the influence from different retention modifiers was performed for a series of benzodiazepinones. This demonstrated the importance of the polymer structure formed from the selectors with different spacer lengths for the enantiodiscriminating ability of the CSPs. (C) 2004 Wiley-Liss, Inc.

Publishing year

2004

Language

English

Pages

614-624

Publication/Series

Chirality

Volume

16

Issue

9

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Organic Chemistry

Keywords

  • enantioselective liquid chromatography
  • racemate resolution
  • selector
  • synthesis
  • benzodiazepinones
  • multiple hydrogen bonding

Status

Published

Research group

  • Chemical Biology and Therapeutics

ISBN/ISSN/Other

  • ISSN: 1520-636X