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Optimizing the friability of a tablet formulation

På svenska

Author

Summary, in English

The impact on tablet friability caused by the loss-on-drying of the granulation, the granule-size distribution, the lubricant concentration, the compression force, and the pre-compression was scrutinized in a factorially designed experiment. A reduction of friability was obtained by reducing the deviation of the granulation loss-on-drying from approximately 4.6%; by decreasing the lubricant concentration; or by increasing the compression force.

Publishing year

1987

Language

English

Pages

1063-1067

Publication/Series

Drug Development and Industrial Pharmacy

Volume

13

Issue

6

Document type

Journal article

Publisher

Marcel Dekker

Topic

  • Probability Theory and Statistics

Status

Published

ISBN/ISSN/Other

  • ISSN: 0363-9045