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D-arabinitol--a marker for invasive candidiasis

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Author

Summary, in English

The five-carbon sugar alcohol D-arabinitol (DA) is a metabolite of most pathogenic Candida species, in vitro as well as in vivo, and can be determined by gas chromatography or enzymatic analysis. Endogenous DA and L-arabinitol (LA) are present in human body fluids, and serum DA and LA increase in renal dysfunction. In prospective clinical studies, elevated DA/LA or DA/creatine ratios in serum or urine have been found in immunocompromised, usually neutropenic, patients with invasive candidiasis. In addition, positive DA results have been obtained several days to weeks before positive blood cultures, and the normalization of DA levels has been correlated with therapeutic response in both humans and animals. However, to date, only a few prospective studies have been conducted in which adequate analytical methods were used. Thus, further investigation of various patient groups is needed to establish the applicability of the 'arabinitol method' in the diagnostic battery for invasive Candida infections.

Publishing year

1999

Language

English

Pages

391-396

Publication/Series

Medical Mycology

Volume

37

Issue

6

Document type

Journal article

Publisher

Oxford University Press

Topic

  • Microbiology in the medical area
  • Infectious Medicine

Status

Published

ISBN/ISSN/Other

  • ISSN: 1460-2709