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Drug Localizations in Tissue by Mass Spectrometry Imaging

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Author

  • Ákos Végvári

Summary, in English

Advances in development of mass spectrometry (MS) are successfully utilized for spatial localization of pharmaceutical compounds in this tissue sections. Today MS instruments can be used in imaging mode when the datasets are generated from the surface of the tissue over an array of acquisition positions. This review is focused on the technological developments of matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) and related sample preparation procedures. MALDI-MSI provides a sensitive and label-free approach for imaging of drugs and their metabolites. Due to these features MALDI-MSI is expected to become a standard technique in pharmaceutical development providing complementary information to current methods.

Publishing year

2015

Language

English

Pages

869-876

Publication/Series

Biomarkers in Medicine

Volume

9

Issue

9

Document type

Journal article review

Publisher

Future Medicine Ltd.

Topic

  • Analytical Chemistry

Keywords

  • Cryo-microtome
  • MALDI matrix
  • MALDI-MSI

Status

Published

ISBN/ISSN/Other

  • ISSN: 1752-0371