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TFEB: Pathogenic role and therapeutic target in Parkinson disease.

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Author

Summary, in English

Parkinson disease (PD) is characterized by the progressive loss of nigral dopamine neurons and the presence of accumulations containing the disease-causing protein SNCA/α-synuclein. Here we review our recent findings describing how SNCA impairs the function of the master regulator of the autophagy-lysosomal pathway (ALP), the transcription factor EB (TFEB), and that genetic or pharmacological stimulation of its activity promotes protection of dopamine neurons. These findings suggest that strategies aimed at enhancing autophagy-mediated degradation of SNCA may hold great promise for disease intervention in PD.

Publishing year

2013

Language

English

Pages

1244-1246

Publication/Series

Autophagy

Volume

9

Issue

8

Document type

Journal article

Publisher

Landes Bioscience

Topic

  • Cell and Molecular Biology

Status

Published

Research group

  • Neurobiology

ISBN/ISSN/Other

  • ISSN: 1554-8635