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Thylakoids Promote Satiety in Healthy Humans. Metabolic Effects and Mechanisms

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Author

Summary, in English

Thylakoids are the photosynthetic membranes of the chloroplasts in green leaves. Thylakoids have been found to promote satiety when added to food, both in animal experimental models and in human. The thylakoids act through inhibition of lipase-colipase catalysed hydrolysis of triacylglycerol, which is the main dietary fat component. The mechanism for inhibition is either a binding of thylakoids to lipase-colipase, which thereby prevents to act as a lipolytic enzyme complex or binding of thylakoids to the triacylglycerol droplet, thereby hindering the access of lipase-colipase to its substrate. Thylakoids consist of proteins and lipids in a membrane structure containing various protein-bound pigments. The thylakoid membranes are fairly resistant to gastrointestinal breakdown, which may be an important property to explain the satiety promoting effect. Satiety is promoted through the release of cholecystokinin, a gastrointestinal hormone that causes an inhibition of gastric emptying and stimulation of satiety mechanism in the brain. The hunger hormone ghrelin is suppressed as well as insulin. In human short-term experiments thylakoids added to food promote satiety signalling. In long-term a reduced body fat mass was observed.

Publishing year

2012

Language

English

Pages

521-531

Publication/Series

ACS Symposium Series

Volume

1093

Document type

Conference paper

Publisher

The American Chemical Society (ACS)

Topic

  • Nutrition and Dietetics
  • Other Clinical Medicine

Keywords

  • Food intake
  • insulin
  • ghrelin
  • leptin
  • abdominal fat
  • body fat
  • CCK
  • blood lipids
  • blood glucose

Conference name

Symposium on Agricultural and Food Derived Natural Products for Preventing and Combating Disease

Conference date

2010-08-22 - 2010-08-26

Status

Published

Research group

  • Appetite Regulation

ISBN/ISSN/Other

  • ISSN: 0097-6156