Direct resolution of naproxen on a non-covalently molecularly imprinted chiral stationary phase

Summary, in English

A synthetic polymer selective for (S)-naproxen was prepared by molecular imprinting. 4-Vinylpyridine and ethylene glycol dimethacrylate were copolymerised in the presence of the template, (S)-naproxen. The template was extracted from the polymer, leaving specific recognition sites, complementary to the template. The polymer was utilized as a stationary phase in HPLC. Racemic naproxen was efficiently resolved on the polymer. Furthermore, the polymer was able to separate naproxen from the structurally related ibuprofen and ketoprofen.

• Author: Maria Kempe; Klaus Mosbach
• Department/s: Nanomedicine and Biomaterials; Pure and Applied Biochemistry
• Publishing year: 1994
• Language: English
• Pages: 276-279
• Publication/Series: Journal of Chromatography A
• Volume: 664
• Issue: 2
• Links: http://dx.doi.org/10.1016/0021-9673(94)87016-0
• Document type: Journal article
• Publisher: Elsevier
• Topic: Biochemistry and Molecular Biology
• Status: Published
• Research group: Nanomedicine and Biomaterials
• ISBN/ISSN/Other: ISSN: 0021-9673