Group A streptococci are protected from amoxicillin-mediated killing by vesicles containing β-lactamase derived from Haemophilus influenzae.

Summary, in English

Group A streptococci (GAS) cause, among other infections, pharyngotonsillitis in children. The species is frequently localized with the Gram-negative respiratory pathogens non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis, which both produce outer membrane vesicles (OMVs). The aim of this study was to investigate whether OMVs isolated from NTHi contain functional β-lactamase and whether the OMVs hydrolyse amoxicillin and thus protect GAS from killing by the antibiotic.

• Author: Viveka Schaar; Ida Uddbäck; Therése Nordström; Kristian Riesbeck
• Department/s: Clinical Microbiology, Malmö
• Publishing year: 2014
• Language: English
• Pages: 117-120
• Publication/Series: Journal of Antimicrobial Chemotherapy
• Volume: 69
• Issue: 1
• Full text: - 528 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/23912886?dopt=Abstract; http://dx.doi.org/10.1093/jac/dkt307
• Document type: Journal article
• Publisher: Oxford University Press
• Topic: Pharmacology and Toxicology
• Status: Published
• Research group: Clinical Microbiology, Malmö
• ISBN/ISSN/Other: ISSN: 1460-2091