Clinical aspects of osseointegration in joint replacement. A histological study of titanium implants

Summary, in English

In an experimental clinical study, 25 implants of pure titanium were inserted into the proximal tibia of 11 volunteer patients, four with rheumatoid arthritis and seven with osteoarthritis. The implants were removed from five weeks to 24 months later and detailed histological analysis was performed. The implants generally healed with direct bone-metal contact, showing so-called osseointegration. Only one of the 21 implants which had been in place for over five months did not show osseointegration, probably because of inadequate primary contact with bone. The presence of rheumatoid disease did not prevent osseointegration, but accompanying osteoporosis seemed to be a risk factor.

• Author: L Linder; Åke Carlsson; L Marsal; Lars Magnus Bjursten; P I Brånemark
• Department/s: Department of Clinical Sciences, Malmö; Department of Experimental Medical Science
• Publishing year: 1988
• Language: English
• Pages: 550-555
• Publication/Series: Journal of Bone and Joint Surgery: British Volume
• Volume: 70-B
• Issue: 4
• Links: http://www.jbjs.org.uk/cgi/reprint/70-B/4/550
• Document type: Journal article
• Publisher: British Editorial Society of Bone & Joint Surgery
• Topic: Medical Biotechnology; Surgery
• Status: Published
• ISBN/ISSN/Other: ISSN: 2044-5377