Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson's disease.

Summary, in English

Despite decades of intensive research, to date, there is no accepted diagnosis for Parkinson's disease (PD) based on biochemical analysis of blood or CSF. However, neurodegeneration in the brains of PD patients begins several years before the manifestation of the clinical symptoms, pointing to serious flaw/limitations in this approach.

• Author: Nour K Majbour; Nishant N. Vaikath; Karin D van Dijk; Mustafa T Ardah; Shiji Varghese; Louise B Vesterager; Liliana P Montezinho; Stephen Poole; Bared Safieh-Garabedian; Takahiko Tokuda; Charlotte E Teunissen; Henk W Berendse; Wilma D J van de Berg; Omar M A El-Agnaf
• Department/s: Neural Plasticity and Repair; MultiPark: Multidisciplinary research focused on Parkinson´s disease
• Publishing year: 2016
• Language: English
• Publication/Series: Molecular Neurodegeneration
• Volume: 11
• Issue: 1
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26782965?dopt=Abstract; http://dx.doi.org/10.1186/s13024-016-0072-9
• Document type: Journal article
• Publisher: BioMed Central (BMC)
• Topic: Neurology
• Status: Published
• Research group: Neural Plasticity and Repair
• ISBN/ISSN/Other: ISSN: 1750-1326