Monitoring Low Molecular Weight Heparins at Therapeutic Levels: Dose-Responses of, and Correlations and Differences between aPTT, Anti-Factor Xa and Thrombin Generation Assays.

Summary, in English

Low molecular weight heparins (LMWH's) are used to prevent and treat thrombosis. Tests for monitoring LMWH's include anti-factor Xa (anti-FXa), activated partial thromboplastin time (aPTT) and thrombin generation. Anti-FXa is the current gold standard despite LMWH's varying affinities for FXa and thrombin.

• Author: Owain Thomas; Emanuel Lybeck; Karin Strandberg; Nahreen Tynngård; Ulf Schött
• Department/s: Anesthesiology and Intensive Care; Clinical Research in Anaesthesia and Intensive Care Medicine; Division of Molecular Medicine and Gene Therapy; Clinical Chemistry, Malmö
• Publishing year: 2015
• Language: English
• Publication/Series: PLoS ONE
• Volume: 10
• Issue: 1
• Full text: - 3 MB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/25625201?dopt=Abstract; http://dx.doi.org/10.1371/journal.pone.0116835
• Document type: Journal article
• Publisher: Public Library of Science (PLoS)
• Topic: Anesthesiology and Intensive Care; Hematology; Medicinal Chemistry
• Status: Published
• Project: Koagulation vid kirurgi och kritisk sjukdom; Haemostatic Safety in Epidural Analgesia
• Research group: Clinical Research in Anaesthesia and Intensive Care Medicine; Clinical Chemistry, Malmö
• ISBN/ISSN/Other: ISSN: 1932-6203